Qualitative and quantitative analysis of cardiac 4D PC-MRI blood flow data

Partners: Heart Center in Leipzig (Matthias Gutberlet, Matthias Grothoff)

The genesis and progression of cardiovascular diseases (CVDs) depend on various factors. A better comprehension of patient-specific blood flow hemodynamics has great potential to increase their diagnosis, support treatment decision-making and provide a realistic forecast of such pathologies, facilitating a better implementation of preventative measures. Four-dimensional phase-contrast magnetic resonance imaging (4D PC-MRI) gained increasing importance and clinical attention in recent years. It is a non-invasive imaging modality that allows for time-resolved, three-dimensional measurement of blood flow information. The resulting 4D grid data, which contain vectors that represent the blood flow direction and velocity, are of limited spatio-temporal resolution and suffer from multiple artifacts, making complex image processing methods a prerequisite. Qualitative data analysis aims to depict the course of the blood flow with emphasis on specific flow patterns, such as vortex flow, which can be an indicator for different cardiovascular diseases. For this purpose, flow visualization techniques can be adapted to the cardiac context. Quantitative data analysis facilitates assessment of, e.g., the cardiac function by evaluating stroke volumes, heart valve performances by evaluating percentaged back flows, and fluid-vessel wall interactions by evaluating wall shear stress.

In this project both qualitative and quantitative data evaluation methods are developed, embedded in a developed software prototype with a guided workflow.

• A semi-automatic extraction of vortex flow was established that is based on the line predicates methodology and preserves visually appealing path lines with long and continuous courses. It was tailored towards our targeted user group: Radiologists focused on the cardiovascular system and cardiologists. The extracted path lines were used to establish an overview visualization of aortic vortex flow and to adapt the speed of videos so that the display vortical flow behavior is enhanced. Vortices were grouped into single entities (clustering) and subsequently analyzed according to different criteria that describe properties, such as their rotation direction and elongation. Based on this classification, a simplifying glyph visualization was established.

• Moreover, the improved quantification of flow rate-based measures was addressed, such as stroke volumes, which are prone to errors especially in case of pathologic vortex flow. A robust procedure was developed that analyzes multiple, systematically generated configurations of required measuring planes and evaluates the resulting sample distributions. Additionally, the flow rate calculation is influenced by the dynamic morphology. Therefore, a semi-automatic extraction of corresponding motion information was established and incorporated in an adapted quantification.

Contact

Name Dr.-Ing. Benjamin Köhler
Address Otto-von-Guericke-Universität Magdeburg,
Fakultät für Informatik,
Institut für Simulation und Grafik,
Universitätsplatz 2,
39016 Magdeburg
Phone (+49 391) 67-5 14 31
Fax (+49 391) 67-1 11 64

Publications


Benjamin Behrendt, Sebastian Ebel, Matthias Gutberlet, Bernhard Preim
Eurographics Workshop on Visual Computing for Biology and Medicine, in print, 2018
BIBTeX
@InProceedings{Behrendt_2018_VCBM,
author = {Benjamin Behrendt and Sebastian Ebel and Matthias Gutberlet and Bernhard Preim},
title = {{A Framework for Visual Comparison of 4D PC-MRI Aortic Blood Flow Data}},
booktitle = {Eurographics Workshop on Visual Computing for Biology and Medicine},
year = {2018},
editor = {Puig Puig, Anna and Schultz, Thomas and Vilanova, Anna and Hotz, Ingrid and Kozlikova, Barbora and Vázquez, Pere-Pau},
publisher = {The Eurographics Association},
doi = {10.2312/vcbm.20181236},
isbn = {978-3-03868-056-7},
issn = {2070-5786},
}
Benjamin Köhler, Matthias Grothoff, Matthias Gutberlet, Bernhard Preim
EuroVis 2018: Eurographics / IEEE VGTC Conference on Visualization 2018, in print, 2018
BIBTeX
@InProceedings{Koehler_2018_EuroVIS,
Title = {{Pressure-based vortex extraction in cardiac 4D PC-MRI blood flow data}},
Author = {Benjamin Köhler and Matthias Grothoff and Matthias Gutberlet and Bernhard Preim},
Booktitle = {{EuroVis 2018: Eurographics / IEEE VGTC Conference on Visualization 2018}},
Year = {2018},
Pages = {to appear}
}
Benjamin Köhler, Matthias Grothoff, Matthias Gutberlet, Bernhard Preim
Vision Modelling und Visualization (VMV), in print, 2017
BIBTeX
Media
@InProceedings{Koehler_2017_VMV,
Title = {{Visualization of Cardiac Blood Flow Using Anisotropic Ambient Occlusion for Lines}},
Author = {Benjamin Köhler and Matthias Grothoff and Matthias Gutberlet and Bernhard Preim},
Booktitle = {{Vision, Modelling und Visualization (VMV)}},
Year = {2017},
Address = {Bonn},
Month = {Sebtember}
}
Visualization of Cardiac Blood Flow Using Anisotropic Ambient Occlusion for Lines
Benjamin Behrendt, Benjamin Köhler, Uta Preim, Bernhard Preim
Bildverarbeitung für die Medizin (BVM), pp. 188-193, 2016
BIBTeX
Media
@InProceedings{Behrendt_2016_BVM,
Title = {{Enhancing Visibility of Blood Flow in Volume Rendered Cardiac 4D PC-MRI Data}},
Author = {Benjamin Behrendt and Benjamin Köhler and Uta Preim and Bernhard Preim},
Booktitle = {{Bildverarbeitung für die Medizin (BVM)}},
Year = {2016},
Address = {Berlin},
Pages = {188--193},
Keywords = {BVM,d},
Owner = {behrendt},
Timestamp = {2016.01.08}
}
Benjamin Behrendt: Enhancing Visibility of Blood Flow in Volume Rendered Cardiac 4D PC-MRI Data
Four-dimensional phase-contrast magnetic resonance imaging (4D PC-MRI ) is a method to non-invasively acquire blood flow in the aorta. This flow is commonly visualized as path lines inside of the vessels. Direct volume rendering (DVR) uses a transfer function to directly render the dataset without needing a manual segmentation. Since the transfer function can be manipulated on the fly, DVR allows fast exploration of the dataset. Using a simple intensity-based transfer function, however, either the intravascular blood flow would be hidden behind the vessel's front side or the entire vessel has to be culled from the visualization. Therefore, we propose an automated mechanism that reveals the vessel anatomy by removing their front sides based on the viewing direction. This creates an effect similar to frontface culling on surface renderings. The visibility of focus objects inside the anatomy is guaranteed while spatial awareness is mostly maintained due to the presence of anatomical structures as context information. While we were able to confirm the effectiveness of our method in an interview with a collaborating radiologist, it still proved to be somewhat limited by the data quality and lack of a manual segmentation.
Benjamin Köhler, Silvia Born, Roy F. P. Van Pelt, Anja Hennemuth, Uta Preim, Bernhard Preim
Computer Graphics Forum, , in print, 2016
BIBTeX
@Article{Koehler_2016_CGF,
Title = {{A Survey of Cardiac 4D PC-MRI Data Processing}},
Author = {Benjamin Köhler and Silvia Born and Roy F. P. Van Pelt and Anja Hennemuth and Uta Preim and Bernhard Preim},
Journal = {Computer Graphics Forum},
Year = {2016},
Keywords = {CGF,d},
Owner = {behrendt},
Timestamp = {2016.02.25}
}
Benjamin Köhler, Uta Preim, Matthias Grothoff, Matthias Gutberlet, Bernhard Preim
Bildverarbeitung für die Medizin (BVM), pp. 194-199, 2016
BIBTeX
Media
@InProceedings{Koehler_2016_BVM,
Title = {{Adaptive Animations of Vortex Flow Extracted from Cardiac 4D PC-MRI Data}},
Author = {Benjamin Köhler and Uta Preim and Matthias Grothoff and Matthias Gutberlet and Bernhard Preim},
Booktitle = {{Bildverarbeitung für die Medizin (BVM)}},
Year = {2016},
Pages = {194--199},
Keywords = {BVM,d},
Owner = {behrendt},
Timestamp = {2016.01.08}
}
Adaptive Animations of Vortex Flow Extracted from Cardiac 4D PC-MRI Data
Monique Meuschke, Kai Lawonn, Benjamin Köhler, Uta Preim, Bernhard Preim
Bildverarbeitung für die Medizin (BVM), pp. 182-187, 2016
BIBTeX
@InProceedings{Meuschke_2016_BVM,
Title = {{Clustering of Aortic Vortex Flow in Cardiac 4D PC-MRI Data}},
Author = {Monique Meuschke and Kai Lawonn and Benjamin Köhler and Uta Preim and Bernhard Preim},
Booktitle = {{Bildverarbeitung für die Medizin (BVM)}},
Year = {2016},
Pages = {182--187},
Keywords = {BVM,d},
Owner = {behrendt},
Timestamp = {2016.01.08}
}
Monique Meuschke, Benjamin Köhler, Uta Preim, Bernhard Preim, Kai Lawonn
EuroVis 2016: Eurographics / IEEE VGTC Conference on Visualization 2016, pp. 351-360, 2016
BIBTeX
Media
@InProceedings{Meuschke_2016_EuroVis,
Title = {{Semi-automatic Vortex Flow Classification in 4D PC-MRI Data of the Aorta}},
Author = {Monique Meuschke and Benjamin Köhler and Uta Preim and Bernhard Preim and Kai Lawonn},
Booktitle = {{EuroVis 2016: Eurographics / IEEE VGTC Conference on Visualization 2016}},
Year = {2016},
Number = {3},
Pages = {351--360},
Volume = {35},
Keywords = {EuroVis,d},
Owner = {behrendt},
Timestamp = {2016.04.22}
}
Semi-automatic Vortex Flow Classification in 4D PC-MRI Data of the Aorta
Benjamin Köhler, Uta Preim, M. Grothoff, M. Gutberlet, K. Fischbach, Bernhard Preim
Comp Graph Forum, , in print, 2015
BIBTeX
@Article{Koehler_2015_CGF,
Title = {{Robust Cardiac Function Assessment in 4D PC-MRI Data of the Aorta and Pulmonary Artery}},
Author = {Benjamin Köhler and Uta Preim and M. Grothoff and M. Gutberlet and K. Fischbach and Bernhard Preim},
Journal = {{Comp Graph Forum}},
Year = {2015},
Owner = {schumann},
Timestamp = {2015.06.04}
}
Benjamin Köhler, Uta Preim, Matthias Grothoff, Matthias Gutberlet, Katharina Fischbach, Bernhard Preim
Eurographics Short Papers and Medical Prize Awards, in print, 2015
BIBTeX
@InProceedings{Koehler_2015_EG,
Title = {{Guided Analysis of Cardiac 4D PC-MRI Blood Flow Data}},
Author = {Benjamin Köhler and Uta Preim and Matthias Grothoff and Matthias Gutberlet and Katharina Fischbach and Bernhard Preim},
Booktitle = {{Eurographics Short Papers and Medical Prize Awards}},
Year = {2015},
Keywords = {EG,d},
Owner = {behrendt},
Timestamp = {2015.09.23}
}
Benjamin Köhler, Silvia Born, Roy F.P. van Pelt, Uta Preim, Bernhard Preim
Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM), pp. 139-148, 2015
BIBTeX
@InProceedings{Koehler_2015_VCBM,
Title = {{A Survey of Cardiac 4D PC-MRI Data Processing}},
Author = {Benjamin Köhler and Silvia Born and Roy F.P. van Pelt and Uta Preim and Bernhard Preim},
Booktitle = {{Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM)}},
Year = {2015},
Address = {Chester, UK},
Month = {September},
Pages = {139--148},
Owner = {schumann},
Timestamp = {2015.09.18}
}
Benjamin Köhler, Monique Meuschke, Uta Preim, Katharina Fischbach, Matthias Gutberlet, Bernhard Preim
Proc. of Bildverarbeitung für die Medizin, pp. 257-261, 2015
BIBTeX
@InProceedings{koehler_2015_bvm,
Title = {{Two-Dimensional Plot Visualization of Aortic Vortex Flow in Cardiac 4D PC-MRI Data}},
Author = {Benjamin Köhler and Monique Meuschke and Uta Preim and Katharina Fischbach and Matthias Gutberlet and Bernhard Preim},
Booktitle = {{Proc. of Bildverarbeitung für die Medizin}},
Year = {2015},
Pages = {257-261},
Owner = {klemm},
Timestamp = {2015.04.13}
}
Benjamin Köhler, Uta Preim, Matthias Grothoff, Matthias Gutberlet, Katharina Fischbach, Bernhard Preim
International Journal of Computer-Assisted Radiology and Surgery (IJCARS), pp. 1-11, 2015
BIBTeX
Media
@InProceedings{Koehler_2015_IJCARS,
Title = {{Motion-aware stroke volume quantification in 4D PC-MRI data of the human aorta}},
Author = {Benjamin Köhler and Uta Preim and Matthias Grothoff and Matthias Gutberlet and Katharina Fischbach and Bernhard Preim},
Booktitle = {{International Journal of Computer-Assisted Radiology and Surgery (IJCARS)}},
Year = {2015},
Pages = {1--11},
Publisher = {Springer},
Keywords = {IJCARS,d},
Owner = {behrendt},
Timestamp = {2015.09.23}
}
Motion-Aware Stroke Volume Quantification in 4D PC-MRI Data of the Human Aorta
Benjamin Köhler, Uta Preim, Matthias Gutberlet, Katharina Fischbach, Bernhard Preim
Proc. of Eurographics Workshop on Visual Computing for Biology and Medicine (EG VCBM), pp. 1-10, 2014
BIBTeX
@InProceedings{Koehler_2014_VCBM,
Title = {{Robust Cardiac Function Assessment in 4D PC-MRI Data}},
Author = {Benjamin Köhler and Uta Preim and Matthias Gutberlet and Katharina Fischbach and Bernhard Preim},
Booktitle = {{Proc. of Eurographics Workshop on Visual Computing for Biology and Medicine (EG VCBM)}},
Year = {2014},
Address = {Wien},
Month = {04.-05. September},
Pages = {1--10},
Owner = {schumann},
Timestamp = {2014.08.19}
}
B. Köhler, R. Gasteiger, U. Preim, H. Theisel, M. Gutberlet, B. Preim
IEEE Transactions on Visualization and Computer Graphics (TVCG), 19(12), pp. 2773-2782, 2013
BIBTeX
Media
@Article{Koehler_2013_TVCG,
Title = {{Semi-Automatic Vortex Extraction in 4D PC-MRI Cardiac Blood Flow Data using Line Predicates}},
Author = {B. Köhler and R. Gasteiger and U. Preim and H. Theisel and M. Gutberlet and B. Preim},
Journal = {{IEEE Transactions on Visualization and Computer Graphics (TVCG)}},
Year = {2013},
Pages = {2773--2782},
Volume = {19(12)},
Owner = {schumann},
Timestamp = {2013.08.08}
}
Semi-Automatic Vortex Extraction in 4D PC-MRI Cardiac Blood Flow Data using Line Predicates
Benjamin Köhler, Mathias Neugebauer, Rocco Gasteiger, Gábor Janiga, Oliver Speck, Bernhard Preim
Bildverarbeitung für die Medizin, pp. 81-86, 2012
BIBTeX
@InProceedings{Koehler_2012_BVM,
Title = {{Surface-Based Seeding for Blood Flow Exploration}},
Author = {Benjamin Köhler and Mathias Neugebauer and Rocco Gasteiger and Gábor Janiga and Oliver Speck and Bernhard Preim},
Booktitle = {{Bildverarbeitung für die Medizin}},
Year = {2012},
Address = {Berlin},
Month = {18.-20. März},
Pages = {81--86},
Owner = {schumann},
Timestamp = {2012.03.21}
}

Images